Set amid the mangrove swamps, coastal lagoons, and stretches of coral reef in Portobelo National Park, this Design Hotels property features just five colorful villas. The “houses” range from a small, one-bedroom retreat nestled near a waterfall, to an over 8,000-square-foot residence spread over two floors. The whole property is awash in a kaleidoscope of vibrant hues, from the bright interiors with their boldly patterned tiles, decorative fabrics, and local artwork, to the multi-colored lounge chairs surrounding the infinity pool, which seems to merge seamlessly with the turquoise Portobelo Bay. Those seeking adventure can take a deep-sea dive to explore the wreck of a C-45 airplane, while guests looking to relax can book an outdoor massage on the hotel’s century-old barge.